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Thus, changes in the GSH/GSSG ratio are fundamental in the fine-tuning of signal transduction, even under mild oxidative stress that underlies physiological events such as cell cycle regulation and other cellular processes (Schafer and Buettner, 2001)

Murphy RA, Stafford RM, Petrasovits BA, Boone MA, Valentovic MA (2017) Establishment of HK-2 cells as a relevant model to study tenofovir-induced cytotoxicity

Evaluation helps determine whether factors such as metabolism, nutrient status, hormonal balance, or lifestyle variables may be contributing

Glutathione: The Master Antioxidant Glutathione is popularly known as the master antioxidant, a tripeptide that naturally occurs and comprises three amino acids: cysteine, glutamine, and glycine

These effects can be partially reversed by restoring GSH levels, suggesting that GSH may contribute to cell death-associated responses in a context-dependent manner 212

Therefore, PS exposure, a characteristic of suicidal erythrocyte death or eryptosis, accelerates the clearance of affected erythrocytes from the circulating blood